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We began to understand the basic electrical phenomenon that neurons use in order to communicate among themselves, the action potential, in the decade of 1950 (Alan Lloyd Hodgkin, Andrew Huxley and John Eccles).
It was in the decade of 1960 that we became aware of how basic neuronal networks code stimuli and thus basic concepts are possible (David H. The molecular revolution swept across US universities in the decade of 1980.
Nerves that transmit signals from the brain are called motor or efferent nerves, while those nerves that transmit information from the body to the CNS are called sensory or afferent.
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Nerves are large enough to have been recognized by the ancient Egyptians, Greeks, and Romans, but their internal structure was not understood until it became possible to examine them using a microscope.
"It is difficult to believe that until approximately year 1900 it was not known that neurons are the basic units of the brain (Santiago Ram? Equally surprising is the fact that the concept of chemical transmission in the brain was not known until around 1930 (Henry Hallett Dale) and (Otto Loewi).